Tier 2 — strong

Efficacy and safety of berberine plus 5-ASA for ulcerative colitis: A systematic review and meta-analysis

Li J, Zhang C, Xu Y, Yang L
PloS one 2024 19(9):e0309144

Bibliography

PubMed
PMID 39241013
PubMed Central
PMC11379390
DOI
10.1371/journal.pone.0309144
Funding
The authors reported no specific funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
Sample10 randomized trials; 952 participants
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

Berberine added to 5-ASA improved several reported disease-activity measures, without a significant difference in adverse reactions.

Key findings

  • Berberine added to 5-ASA improved several reported disease-activity measures, without a significant difference in adverse reactions.

What this study can and cannot tell us

Small low-bias trials are needed. Some abstract confidence intervals appear inconsistent; do not reproduce those estimates without source verification.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology