Tier 2 — strong

The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review

Nie Q, Li M, Huang C, Yuan Y, Liang Q, Ma X, Qiu T, Li J
Journal of translational medicine 2024 22(1):225

Bibliography

PubMed
PMID 38429794
PubMed Central
PMC10908013
Funding
Supported through the Foshan Fourteenth Five-Year Plan key-specialty construction program.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
Sample10 randomized trials; 811 participants
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

The synthesis reported better liver-enzyme, lipid and insulin-resistance measures across earlier NAFLD trials.

Key findings

  • The synthesis reported better liver-enzyme, lipid and insulin-resistance measures across earlier NAFLD trials.

What this study can and cannot tell us

Predates the 2026 BRAVO trial. Liver enzymes and metabolic surrogates do not establish histologic or fibrosis benefit.

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Editorial review

Reviewed by the Biohack Blueprint research team

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