Tier 2 — strong

Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zhao JV, Huang X, Zhang J, Chan YH, Tse HF, Blais JE
The Journal of nutrition 2023 153(10):2939-2950

Bibliography

PubMed
PMID 37598753
DOI
10.1016/j.tjnut.2023.08.016
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
Sample20 studies; 1761 participants
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

Placebo-controlled trials showed modest average improvements in glycemic and insulin-related markers. Possible sex differences were based on limited subgroup data.

Key findings

  • Placebo-controlled trials showed modest average improvements in glycemic and insulin-related markers. Possible sex differences were based on limited subgroup data.

What this study can and cannot tell us

Sex comparisons were uneven and need replication; the same participants can contribute to several outcomes.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology