Tier 2 — strong

The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta‑analysis of randomized controlled trials

Lu Y, Zhang X, He J, Dai Z, Shi P, Lu Y, Chang F
Inflammopharmacology 2022 30(3):1063-1077

Bibliography

PubMed
PMID 35352233
PubMed Central
PMC9135894
Funding
Reported funding sources: http://dx.doi.org/10.13039/100007847Natural Science Foundation of Jilin Province. Grant and funder-role details are in the publication.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
Sample52 studies; 4616 patients
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

The synthesis reported reductions in selected inflammatory markers in Chinese metabolic-disease populations.

Key findings

  • The synthesis reported reductions in selected inflammatory markers in Chinese metabolic-disease populations.

What this study can and cannot tell us

Small-trial methods, heterogeneous illnesses and biomarker endpoints limit clinical conclusions.

Editorial review

Reviewed by the Biohack Blueprint research team

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