Tier 2 — strong

Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis

Fang S, Guo S, Du S, Cao Z, Yang Y, Su X, Wei W

Journal of ethnopharmacology 2022 282:114617

Bibliography

PubMed: PMID 34509605
DOI: 10.1016/j.jep.2021.114617
Funding: Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests: A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Design	Systematic review and meta-analysis
Model	Published human studies
Sample	3 randomized trials; 1076 participants
Intervention	Evidence synthesis; interventions and comparators vary across included studies
Duration	No new treatment; included-study durations vary
Endpoints	Pooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

The synthesis supported lower adenoma recurrence but found more adverse events than placebo, mainly constipation.

The synthesis supported lower adenoma recurrence but found more adverse events than placebo, mainly constipation.

Follow-up denominators differ across years. Adenoma recurrence is not colorectal-cancer incidence or mortality.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Last verified 22 October 2026