Tier 2 — strong

Berberine for the treatment of hypertension: A systematic review

Suadoni MT, Atherton I
Complementary therapies in clinical practice 2021 42:101287

Bibliography

PubMed
PMID 33461163
DOI
10.1016/j.ctcp.2020.101287
Funding
Indexed support: Burdett Trust for Nursing. See the publication for grant details.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
SampleClinical randomized trials; outcome-specific denominators vary
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

The review concluded that evidence for treating hypertension with berberine was limited, low quality and inconclusive.

Key findings

  • The review concluded that evidence for treating hypertension with berberine was limited, low quality and inconclusive.

What this study can and cannot tell us

Several interventions contained additional herbs or ingredients, preventing attribution to berberine alone.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology