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The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin Density, Texture and Other Parameters: A Randomised, Double-Blind, Placebo-Controlled Trial

Katja Žmitek, Janko Žmitek, Hristo Hristov, Mirjam Rogl Butina, Petra Keršmanc, Tina Pogačnik
Nutrients 2024 16(12):1908

Bibliography

PubMed
PMID 38931263
PubMed Central
PMC11206740
DOI
10.3390/nu16121908
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Funded by the Slovenian Research and Innovation Agency (Research Programme P3-0395: Nutrition and Public Health) and Tosla d.o.o. Tosla produced the study products. The authors reported that funders were not involved in study design, data collection, analysis, interpretation, manuscript writing, or the decision to submit.
Competing interests
The authors declared no conflicts of interest. Tosla d.o.o., which co-funded the study, produced the study products.

Study snapshot

DesignThree-arm randomized, double-blind, placebo-controlled trial
ModelWomen aged 40–65 years with visible signs of skin ageing
Sample90 randomized; 87 completed (30 collagen + vitamin C, 28 collagen + vitamin C + hyaluronic acid, 29 placebo)
InterventionDaily for 16 weeks: 5 g hydrolysed collagen + 80 mg vitamin C; or the same formula + 30 mg hyaluronic acid; or placebo.
Duration16 weeks
EndpointsDermis density; Dermis thickness; Skin texture and roughness; Wrinkle severity and volume; Skin elasticity; Skin hydration

What the study showed, in plain terms

This 16-week trial compared hydrolysed collagen plus vitamin C against the same formula with added hyaluronic acid and against placebo. Both active products improved some dermal-density, texture and wrinkle measures, but neither improved hydration or elasticity versus placebo, and adding 30 mg hyaluronic acid did not produce superior results.

Key findings

Both collagen-containing formulas improved dermis density and several texture/wrinkle measures versus placebo. Neither active arm significantly improved skin hydration or elasticity. The 30 mg hyaluronic-acid addition did not outperform collagen plus vitamin C alone on the assessed outcomes.

What this study can and cannot tell us

The collagen arm also contained 80 mg vitamin C, so the study does not isolate collagen alone. The added-HA arm used only one HA dose (30 mg). Tosla d.o.o. co-funded the study and manufactured the study products. The sample consisted of women aged 40–65 years and follow-up lasted 16 weeks.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology