Tier 4 — mechanistic

Behavioral characterisation of the flavonoids apigenin and chrysin

P. Zanoli, R. Avallone, M. Baraldi
Fitoterapia 2000 71 Suppl 1:S117-S123

Bibliography

PubMed
PMID 10930722
DOI
10.1016/S0367-326X(00)00186-6
Funding
Not reported in the indexed record reviewed.
Competing interests
Not reported in the indexed record reviewed.

Study snapshot

DesignAcute comparative animal behavioral study
ModelRats
SampleExact total sample size was not reported in the PubMed abstract.
InterventionAcute apigenin or chrysin administration; locomotor effects were observed at a minimum effective dose of 25 mg/kg
DurationAcute administration
EndpointsLocomotor activity; Sedative-like behavior; Anxiolytic-like behavior

What the study showed, in plain terms

This rat study compared the behavioral effects of apigenin and chrysin, two flavonoids often discussed for calming effects.

Key findings

Both flavonoids reduced locomotor activity at a minimum effective dose of 25 mg/kg under the study conditions. The work did not provide convincing evidence that apigenin produced a classic benzodiazepine-like anxiolytic profile.

What this study can and cannot tell us

The findings come from acute rat experiments, not oral human supplementation. Reduced locomotor activity is not equivalent to improved sleep quality or relief of clinical anxiety.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology