Tier 1 — highest

Effect of Betaine on Reducing Body Fat-A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Xiang Gao, Huijun Zhang, Xiao-Fei Guo, Kelei Li, Shan Li, Duo Li
Nutrients 2019 11(10):2480

Bibliography

PubMed
PMID 31623137
PubMed Central
PMC6835719
DOI
10.3390/nu11102480
Funding
Indexed grant support: 81773433 — National Natural Science Foundation of China; 2017YYSP007 — Key scientific Research Projects in Shandong Provence; ZR2019PC014 — Natural Science Foundation of Shandong Province; CNS-DSM2018A30 — 2018 Chinese Nutrition Society (CNS) Nutrition Research Foundation-DSM Research Fund. The indexed list may not contain the complete funding declaration.
Competing interests
Reported disclosure: The authors declare no conflict of interest.

Study snapshot

DesignSystematic review and meta-analysis of RCTs
ModelEvidence synthesis; mixed research models
Sample6 studies; 195 participants
InterventionBetaine supplementation versus controls
DurationSearch through September 2019
EndpointsFat mass; Body-fat percentage; Weight

What the study showed, in plain terms

Published in 2019, this source examined safety assessments and evidence synthesis. Its evidence base was 6 studies; 195 participants. It evaluated Betaine supplementation versus controls across Search through September 2019.

The analysis reported lower fat mass and body-fat percentage but no clear change in weight or BMI.

Few small studies; later synthesis did not reproduce a clear overall body-composition benefit.

Continue with TMG Data Center

Continue with TMG for Weight Loss: Body-Fat Findings and Their Limits

Key findings

  • The analysis reported lower fat mass and body-fat percentage but no clear change in weight or BMI.
  • The recorded outcome domains were Fat mass; Body-fat percentage; Weight.
  • This synthesis reuses the included study populations; it is not an additional randomized participant cohort.

What this study can and cannot tell us

  • Few small studies; later synthesis did not reproduce a clear overall body-composition benefit.
  • Pooled estimates depend on the included trials and may share participants with companion publications or other reviews. A statistically significant surrogate outcome does not establish disease prevention.
  • Source basis: Accessible full-text extract plus indexed bibliographic data. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 1
Effects of betaine supplementation on cardiovascular markers: A systematic review and Meta-analysis
Damoon Ashtary-Larky et al. · Critical reviews in food science and nutrition · 2022
Tier 1
Betaine Supplementation Moderately Increases Total Cholesterol Levels: A Systematic Review and Meta-Analysis
Emilia E Zawieja et al. · Journal of dietary supplements · 2021
Tier 2
Safety of betaine as a novel food pursuant to Regulation (EC) No 258/97
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) et al. · EFSA journal. European Food Safety Authority · 2017
Tier 2
Safety of betaine as a novel food pursuant to Regulation (EU) 2015/2283
EFSA Panel on Nutrition, Novel Foods and Food Allergens (EFSA NDA Panel) et al. · EFSA journal. European Food Safety Authority · 2019
Tier 4
Postauthorization safety study of betaine anhydrous
Ulrike Mütze et al. · Journal of inherited metabolic disease · 2022

Citation network

Articles citing this research paper

2 articles

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology