Tier 2 — strong

The effects of two sodium lauryl sulphate-containing toothpastes with and without betaine on human oral mucosa in vivo

Irma Rantanen, Kirsti Jutila, Ingrid Nicander, Jorma Tenovuo, Eva Söderling
Swedish dental journal 2003 27(1):31-34

Bibliography

PubMed
PMID 12704946
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignRandomized double-blind crossover experiment
ModelHuman participants
Sample20 volunteers
InterventionToothpastes containing SLS with or without 4% betaine; detergent-free comparison
Duration15-minute exposure; assessment to 45 minutes
EndpointsOral irritation; Toothpaste formulation

What the study showed, in plain terms

Published in 2003, this source examined betaine hcl and topical formulations. Design: Randomized double-blind crossover experiment. Sample/model: 20 volunteers. The exposure or intervention was Toothpastes containing SLS with or without 4% betaine; detergent-free comparison. Follow-up or treatment period: 15-minute exposure; assessment to 45 minutes.

Adding betaine did not reduce irritation from the tested SLS toothpaste, while the detergent-free formulation was nonirritating.

A formulation-specific local-use result; the overall product composition matters.

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Continue with Betaine Anhydrous vs Betaine HCl: Which Form Is TMG?

Key findings

  • Adding betaine did not reduce irritation from the tested SLS toothpaste, while the detergent-free formulation was nonirritating.
  • The recorded outcome domains were Oral irritation; Toothpaste formulation.
  • The result applies to the tested exposure: Toothpastes containing SLS with or without 4% betaine; detergent-free comparison; 15-minute exposure; assessment to 45 minutes.

What this study can and cannot tell us

  • A formulation-specific local-use result; the overall product composition matters.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology