Tier 2 — strong

The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively

Ingrid Nicander, Peter Aberg, Stig Ollmar
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2003 9(1):43-49

Bibliography

PubMed
PMID 12535284
DOI
10.1034/j.1600-0846.2003.00362.x
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled skin patch experiment
ModelHuman participants
Sample28 healthy volunteers
InterventionLiquid soaps with differing betaine concentrations
Duration24-hour exposure plus assessment after removal
EndpointsSkin irritation; Water loss; Electrical impedance

What the study showed, in plain terms

Published in 2003, this source examined betaine hcl and topical formulations. Design: Randomized controlled skin patch experiment. Sample/model: 28 healthy volunteers. The exposure or intervention was Liquid soaps with differing betaine concentrations. Follow-up or treatment period: 24-hour exposure plus assessment after removal.

Betaine-containing soaps were generally less irritating, but higher betaine concentration did not consistently reduce irritation further.

Differences among complete soap formulations were small; local skin testing does not establish oral-supplement efficacy.

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Key findings

  • Betaine-containing soaps were generally less irritating, but higher betaine concentration did not consistently reduce irritation further.
  • The recorded outcome domains were Skin irritation; Water loss; Electrical impedance.
  • The result applies to the tested exposure: Liquid soaps with differing betaine concentrations; 24-hour exposure plus assessment after removal.

What this study can and cannot tell us

  • Differences among complete soap formulations were small; local skin testing does not establish oral-supplement efficacy.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology