Tier 4 — mechanistic

Apigenin enhancing oxidative resistance and proteostasis to extend lifespan via PTEN-mediated AKT signalling pathway

Zhengqiong Sun, Lei Li, Lei Zhang
BBA - Molecular Basis of Disease 2025 1871(3):167670

Bibliography

PubMed
PMID 39826849
DOI
10.1016/j.bbadis.2025.167670

Study snapshot

DesignExperimental lifespan study
ModelSaccharomyces cerevisiae and Drosophila melanogaster
Sample
InterventionApigenin across yeast lifespan assays and dietary apigenin in flies
Duration
EndpointsReplicative and chronological lifespan; Fly lifespan; Oxidative stress resistance; Proteostasis; PTEN/AKT signaling

What the study showed, in plain terms

This 2025 study directly tested whether apigenin changes lifespan in yeast and fruit flies.

Key findings

Apigenin extended lifespan in yeast and male and female flies, improved oxidative-stress resistance and proteostasis, and implicated PTEN/AKT-related signaling. It also rescued shortened lifespan in a high-sucrose fly model.

What this study can and cannot tell us

Yeast and flies are model organisms. These findings do not establish human lifespan extension or a clinically effective oral dose.

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Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology