Tier 2 — strong

Effects of quercetin ingestion on neuromuscular system following single session of resistance exercise at differing intensities in older adults

Taichi Nishikawa, Ryosuke Takeda, Marino Karaki, Kaito Igawa, Kohei Watanabe
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2025 50:1-13

Bibliography

PubMed
PMID 41056568
DOI
10.1139/apnm-2025-0169
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
Reported disclosure: The authors declare there are no competing interests.

Study snapshot

DesignRandomized crossover acute exercise study
ModelHuman intervention research
Sample38 older adults across three exercise-intensity groups
InterventionQuercetin glycoside 500 mg versus placebo before exercise
DurationTwo acute exercise sessions
EndpointsSource-specific outcomes described in the key findings

What the study showed, in plain terms

Published in 2025, this source examined exercise and recovery. Design: Randomized crossover acute exercise study. Sample/model: 38 older adults across three exercise-intensity groups. The exposure or intervention was Quercetin glycoside 500 mg versus placebo before exercise. Follow-up or treatment period: Two acute exercise sessions.

Quercetin lowered motor-unit recruitment thresholds. Contractile capacity fell more after low- and moderate-intensity exercise, with no corresponding difference at high intensity.

Acute physiological findings are not proof of improved strength, recovery or long-term function.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Quercetin lowered motor-unit recruitment thresholds.
  • Contractile capacity fell more after low- and moderate-intensity exercise, with no corresponding difference at high intensity.
  • The recorded outcome domains were Source-specific outcomes described in the key findings.
  • The result applies to the tested exposure: Quercetin glycoside 500 mg versus placebo before exercise; Two acute exercise sessions.

What this study can and cannot tell us

  • Acute physiological findings are not proof of improved strength, recovery or long-term function.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Quercetin ingestion alters motor unit behavior and enhances improvement in muscle strength following resistance training in older adults: a randomized, double-blind, controlled trial
Taichi Nishikawa et al. · European journal of nutrition · 2025

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology