Tier 2 — strong

Quercetin ingestion alters motor unit behavior and enhances improvement in muscle strength following resistance training in older adults: a randomized, double-blind, controlled trial

Taichi Nishikawa, Ryosuke Takeda, Saeko Ueda, Kaito Igawa, Tetsuya Hirono, Masamichi Okudaira, Yukiko Mita, Toshiyuki Ohya, Kohei Watanabe
European journal of nutrition 2025 64(3):117

Bibliography

PubMed
PMID 40063125
PubMed Central
PMC11893712
DOI
10.1007/s00394-025-03634-9
Funding
Reported funding/support: http://dx.doi.org/10.13039/501100001691Japan Society for the Promotion of ScienceJPJSBP-82626WatanabeKohei
Competing interests
Reported disclosure: Declarations. Conflict of interest: The authors declare no conflicts of interest.

Study snapshot

DesignRandomized double-blind controlled resistance-training trial
ModelHuman intervention research
Sample26 older adults
InterventionQuercetin glycosides 200 mg/day versus placebo with resistance training
Duration6 weeks
EndpointsExercise performance or recovery

What the study showed, in plain terms

Published in 2025, this source examined exercise and recovery. Design: Randomized double-blind controlled resistance-training trial. Sample/model: 26 older adults. The exposure or intervention was Quercetin glycosides 200 mg/day versus placebo with resistance training. Follow-up or treatment period: 6 weeks.

Strength increased in both groups, with a larger increase in the quercetin group. Muscle mass did not increase.

Small training trial using glycosides. Strength and motor-unit findings are not evidence of muscle hypertrophy or proven long-term functional benefit.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Strength increased in both groups, with a larger increase in the quercetin group.
  • Muscle mass did not increase.
  • The recorded outcome domains were Exercise performance or recovery.
  • The result applies to the tested exposure: Quercetin glycosides 200 mg/day versus placebo with resistance training; 6 weeks.

What this study can and cannot tell us

  • Small training trial using glycosides. Strength and motor-unit findings are not evidence of muscle hypertrophy or proven long-term functional benefit.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: accessible full text and indexed metadata. Missing method details, funding information or participant denominators are not inferred.

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Effects of Quercetin and Citrulline on Nitric Oxide Metabolites and Antioxidant Biomarkers in Trained Cyclists
Jennifer A Kurtz et al. · Nutrients · 2025
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Effects of quercetin ingestion on neuromuscular system following single session of resistance exercise at differing intensities in older adults
Taichi Nishikawa et al. · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2025

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology