Tier 2 — strong

Adding collagen, propolis plus quercetin, bacillus coagulans, hyaluronic acid and chondroitin sulphate to D-mannose avoids symptoms and prevents recurrence in women with recurrent urinary tract infections: a single-blind randomized controlled trial

Gaetano Riemma, Davide Vinci, Marco La Verde, Florindo Mario Caniglia, Gaetano Scalzone, Marco Torella
Expert review of anti-infective therapy 2025 23(7):523-530

Bibliography

PubMed
PMID 40162673
DOI
10.1080/14787210.2025.2487162
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized single-blind three-arm trial
ModelHuman intervention research
SampleWomen aged 21–65 with recurrent urinary infections; total not stated in abstract
InterventionFosfomycin, multi-ingredient D-mannose/propolis-quercetin supplement, or both
DurationOutcomes followed for 12 months
EndpointsSymptoms and quality of life; Urinary or pelvic symptoms

What the study showed, in plain terms

Published in 2025, this source examined prostate and urinary health. Design: Randomized single-blind three-arm trial. Sample/model: Women aged 21–65 with recurrent urinary infections; total not stated in abstract. The exposure or intervention was Fosfomycin, multi-ingredient D-mannose/propolis-quercetin supplement, or both. Follow-up or treatment period: Outcomes followed for 12 months.

The combined regimen reduced recurrent-infection frequency more than either regimen alone and improved urinary symptom measures.

Several ingredients and antibiotic treatment prevent attribution to quercetin. The supplement-alone regimen did not match the combined regimen.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Prostatitis and Chronic Pelvic Pain. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The combined regimen reduced recurrent-infection frequency more than either regimen alone and improved urinary symptom measures.
  • The recorded outcome domains were Symptoms and quality of life; Urinary or pelvic symptoms.
  • The result applies to the tested exposure: Fosfomycin, multi-ingredient D-mannose/propolis-quercetin supplement, or both; Outcomes followed for 12 months.

What this study can and cannot tell us

  • Several ingredients and antibiotic treatment prevent attribution to quercetin. The supplement-alone regimen did not match the combined regimen.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 2
Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer
Susanne M Henning et al. · Food & function · 2020
Tier 2
Efficacy of an orally administered combination of hyaluronic acid, chondroitin sulfate, curcumin and quercetin for the prevention of recurrent urinary tract infections in postmenopausal women
M Torella et al. · European journal of obstetrics, gynecology, and reproductive biology · 2016

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology