Tier 2 — strong

Efficacy of an orally administered combination of hyaluronic acid, chondroitin sulfate, curcumin and quercetin for the prevention of recurrent urinary tract infections in postmenopausal women

M Torella, F Del Deo, A Grimaldi, S A Iervolino, M Pezzella, C Tammaro, P Gallo, C Rappa, P De Franciscis, N Colacurci
European journal of obstetrics, gynecology, and reproductive biology 2016 207:125

Bibliography

PubMed
PMID 27838537
DOI
10.1016/j.ejogrb.2016.10.018
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignProspective three-regimen comparative study
ModelHuman intervention research
Sample145 postmenopausal women with recurrent urinary infections
InterventionHyaluronic acid, chondroitin, curcumin and quercetin, with or without vaginal estrogen
Duration6- and 12-month follow-up
EndpointsSymptoms and quality of life

What the study showed, in plain terms

Published in 2016, this source examined prostate and urinary health. Design: Prospective three-regimen comparative study. Sample/model: 145 postmenopausal women with recurrent urinary infections. The exposure or intervention was Hyaluronic acid, chondroitin, curcumin and quercetin, with or without vaginal estrogen. Follow-up or treatment period: 6- and 12-month follow-up.

The combined oral and estrogen regimen showed greater recurrence and symptom improvements than the single regimens.

Several ingredients and unclear randomization in the abstract. The study cannot isolate quercetin or establish its role as an antibiotic replacement.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Prostatitis and Chronic Pelvic Pain. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The combined oral and estrogen regimen showed greater recurrence and symptom improvements than the single regimens.
  • The recorded outcome domains were Symptoms and quality of life.
  • The result applies to the tested exposure: Hyaluronic acid, chondroitin, curcumin and quercetin, with or without vaginal estrogen; 6- and 12-month follow-up.

What this study can and cannot tell us

  • Several ingredients and unclear randomization in the abstract. The study cannot isolate quercetin or establish its role as an antibiotic replacement.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 2
Adding collagen, propolis plus quercetin, bacillus coagulans, hyaluronic acid and chondroitin sulphate to D-mannose avoids symptoms and prevents recurrence in women with recurrent urinary tract infections: a single-blind randomized controlled trial
Gaetano Riemma et al. · Expert review of anti-infective therapy · 2025
Tier 2
Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer
Susanne M Henning et al. · Food & function · 2020

Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology