Tier 2 — strong

Effects of Quercetin Glycoside Supplementation Combined With Low-Intensity Resistance Training on Muscle Quantity and Stiffness: A Randomized, Controlled Trial

Yuta Otsuka, Naokazu Miyamoto, Akitoshi Nagai, Takayuki Izumo, Masaaki Nakai, Masahiro Fukuda, Takuma Arimitsu, Yosuke Yamada, Takeshi Hashimoto
Frontiers in nutrition 2022 9:912217

Bibliography

PubMed
PMID 35873410
PubMed Central
PMC9298516
DOI
10.3389/fnut.2022.912217
Funding
Reported funding/support: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Competing interests
Reported disclosure: This study received funding from Suntory Wellness Ltd. YO, AN, TI, and MN Were employees of Suntory Wellness Ltd., which manufactures and sells health food products. The funder had the following involvement with the study: the study design, collection, analysis, interpretation of data, the writing of this article, and the decision to submit it for publication. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Study snapshot

DesignRandomized controlled resistance-training trial
ModelHuman intervention research
Sample48 adults completed; age range 50–74 years
InterventionQuercetin glycosides 200 or 500 mg/day versus placebo with low-intensity training
Duration24 weeks
EndpointsExercise performance or recovery

What the study showed, in plain terms

Published in 2022, this source examined exercise and recovery. Design: Randomized controlled resistance-training trial. Sample/model: 48 adults completed; age range 50–74 years. The exposure or intervention was Quercetin glycosides 200 or 500 mg/day versus placebo with low-intensity training. Follow-up or treatment period: 24 weeks.

Passive thigh-muscle stiffness improved, but the primary muscle-area endpoint and lean mass did not differ between groups.

Muscle stiffness and muscle growth are different outcomes. A linked erratum is part of the publication history.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Passive thigh-muscle stiffness improved, but the primary muscle-area endpoint and lean mass did not differ between groups.
  • The recorded outcome domains were Exercise performance or recovery.
  • The result applies to the tested exposure: Quercetin glycosides 200 or 500 mg/day versus placebo with low-intensity training; 24 weeks.

What this study can and cannot tell us

  • Muscle stiffness and muscle growth are different outcomes. A linked erratum is part of the publication history.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: accessible full text and indexed metadata. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 2
Quercetin prophylaxis in prevention of acute mountain sickness (AMS): a randomized, double blind, placebo controlled phase-II clinical trials
Sarada S K Sagi et al. · European journal of nutrition · 2026
Tier 2
Effects of Quercetin and Citrulline on Nitric Oxide Metabolites and Antioxidant Biomarkers in Trained Cyclists
Jennifer A Kurtz et al. · Nutrients · 2025
Tier 2
Quercetin ingestion alters motor unit behavior and enhances improvement in muscle strength following resistance training in older adults: a randomized, double-blind, controlled trial
Taichi Nishikawa et al. · European journal of nutrition · 2025

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology