Tier 2 — strong

Quercetin Modulates IGF-I and IGF-II Levels After Eccentric Exercise-Induced Muscle-Damage: A Placebo-Controlled Study

Paolo Sgrò, Roberta Ceci, Marco Lista, Federica Patrizio, Stefania Sabatini, Francesco Felici, Massimo Sacchetti, Ilenia Bazzucchi, Guglielmo Duranti, Luigi Di Luigi
Frontiers in endocrinology 2021 12:745959

Bibliography

PubMed
PMID 34803913
PubMed Central
PMC8595302
DOI
10.3389/fendo.2021.745959
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
Reported disclosure: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Study snapshot

DesignRandomized double-blind crossover exercise study
ModelHuman intervention research
Sample12 young men
InterventionQuercetin 1,000 mg/day versus placebo
Duration14 days supplementation; recovery tracked for 7 days
EndpointsInflammatory measures

What the study showed, in plain terms

Published in 2021, this source examined exercise and recovery. Design: Randomized double-blind crossover exercise study. Sample/model: 12 young men. The exposure or intervention was Quercetin 1,000 mg/day versus placebo. Follow-up or treatment period: 14 days supplementation; recovery tracked for 7 days.

Exercise-damage markers and IL-6 were lower, with altered timing of IGF-I and IGF-II responses.

Small biomarker-focused exercise study. IGF changes do not establish muscle growth or general hormone benefits.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Exercise-damage markers and IL-6 were lower, with altered timing of IGF-I and IGF-II responses.
  • The recorded outcome domains were Inflammatory measures.
  • The result applies to the tested exposure: Quercetin 1,000 mg/day versus placebo; 14 days supplementation; recovery tracked for 7 days.

What this study can and cannot tell us

  • Small biomarker-focused exercise study. IGF changes do not establish muscle growth or general hormone benefits.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: accessible full text and indexed metadata. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology