Tier 2 — strong

Bioavailability of Quercetin in Humans with a Focus on Interindividual Variation

A Filipa Almeida, Grethe Iren A Borge, Mariusz Piskula, Adriana Tudose, Liliana Tudoreanu, Kateřina Valentová, Gary Williamson, Cláudia N Santos
Comprehensive reviews in food science and food safety 2018 17(3):714-731

Bibliography

PubMed
PMID 33350133
DOI
10.1111/1541-4337.12342
Funding
Indexed grant support: PT2020 — FEDER; IF/01097/2013 — CNS; LD15082 — Ministry of Education, Youth and Sport of the Czech Republic; KV — Ministry of Education, Youth and Sport of the Czech Republic; COST; Project SunnMat/HealthyFood 262300 — Foundation for Research Levy on Agricultural Products; Project No. FP7-613793 — FP7 Food, Agriculture and Fisheries, Biotechnology; Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciência e do Ensino Superior; European Research Council — International. The indexed list may not contain the complete funding declaration.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignNarrative review of human bioavailability and individual variation
ModelNarrative or mixed evidence review
SampleHuman food, beverage, and supplement studies; no new cohort
InterventionQuercetin and circulating or microbiota-derived metabolites
DurationPublished intervention literature
EndpointsExposure and pharmacokinetics

What the study showed, in plain terms

Published in 2018, this source examined forms, absorption and food sources. Its evidence base was Human food, beverage, and supplement studies; no new cohort. It evaluated Quercetin and circulating or microbiota-derived metabolites across Published intervention literature.

Absorption and metabolite profiles vary substantially between people, with possible contributions from gut metabolism and host factors.

Most source studies were small. Proposed genetic, dietary, and microbiome explanations are not validated predictors of individual clinical response.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin Forms: Dihydrate, Phytosome, Liposomal and Glycosides. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Absorption and metabolite profiles vary substantially between people, with possible contributions from gut metabolism and host factors.
  • The recorded outcome domains were Exposure and pharmacokinetics.

What this study can and cannot tell us

  • Most source studies were small. Proposed genetic, dietary, and microbiome explanations are not validated predictors of individual clinical response.
  • The conclusions inherit the limitations of the underlying studies. A narrative interpretation or guideline recommendation is not a new randomized treatment comparison.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology