Tier 4 — mechanistic

Recent advances on the improvement of quercetin bioavailability

Kandemir K, Tomas M, McClements DJ, Capanoglu E
Trends in Food Science & Technology 2022 119:192-200

Bibliography

DOI
10.1016/j.tifs.2021.11.032

Study snapshot

DesignNarrative review
ModelReview of quercetin bioavailability-enhancement formulation strategies (nanoparticles, phytosomes, complexation)
SampleNot applicable — narrative review of existing delivery and pharmacokinetic studies.
InterventionNot applicable — comparison of published quercetin formulation approaches; no original fisetin intervention.
DurationNot applicable — literature review; included studies varied in duration.
EndpointsQuercetin absorption and bioavailability; Formulation and delivery strategies; Limitations of available pharmacokinetic and clinical evidence

What the study showed, in plain terms

This food-science review summarises the various formulation strategies researchers have used to improve how well quercetin — a flavonoid with naturally poor oral absorption — gets absorbed into the body, including nanoparticle, phytosome, and complexation approaches. It's a general food-science and formulation review, not a clinical safety or efficacy study.

Key findings

Quercetin has poor native oral bioavailability, similar to other flavonols. Various delivery-system approaches (nanoencapsulation, phytosome/lecithin complexes, cyclodextrin inclusion) have been developed to improve absorption, with several showing meaningful bioavailability gains in preclinical or limited human pharmacokinetic testing. Does not test fisetin.

What this study can and cannot tell us

Narrative food-science review, not primary clinical data, and does not evaluate fisetin. Use only for general quercetin bioavailability-formulation context.

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Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability