Tier 2 — strong

Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise

Marcos Martin-Rincon, Miriam Gelabert-Rebato, Victor Galvan-Alvarez, Angel Gallego-Selles, Miriam Martinez-Canton, Laura Lopez-Rios, Julia C Wiebe, Saul Martin-Rodriguez, Rafael Arteaga-Ortiz, Cecilia Dorado, Sergio Perez-Regalado, Alfredo Santana, David Morales-Alamo, Jose A L Calbet
Nutrients 2020 12(3):614

Bibliography

PubMed
PMID 32110986
PubMed Central
PMC7146389
DOI
10.3390/nu12030614
Funding
Indexed grant support: DEP2017-86409-C2-1-P — Ministerio de Economía, Industria y Competitividad, Gobierno de España; DEP2015-71171-R — Ministerio de Economía, Industria y Competitividad, Gobierno de España. The indexed list may not contain the complete funding declaration.
Competing interests
Reported disclosure: The present investigation was partially financed by Nektium Pharma S.L, providing with the polyphenolic compounds and participating in the experimental design, although fully excluded from participation in experimental data collection, data analysis and interpretation of results. The remaining funding agencies had no role in study design, data collection, management, data analysis, interpretation of data, writing of the report and the decision to submit the report for publication.

Study snapshot

DesignRandomized double-blind exercise trial
ModelHuman intervention research
Sample57 adults: 24 women and 33 men
InterventionMango-leaf extract 140 mg plus quercetin 140 mg before exercise, with three further doses 8 hours apart
Duration24-hour dosing around a damaging exercise bout
EndpointsExercise performance or recovery; Symptoms and quality of life

What the study showed, in plain terms

Published in 2020, this source examined exercise and recovery. Design: Randomized double-blind exercise trial. Sample/model: 57 adults: 24 women and 33 men. The exposure or intervention was Mango-leaf extract 140 mg plus quercetin 140 mg before exercise, with three further doses 8 hours apart. Follow-up or treatment period: 24-hour dosing around a damaging exercise bout.

The combination reduced reported pain and loss of jumping performance; race times did not improve.

Multi-ingredient acute intervention. Sex-specific biomarker findings and recovery endpoints do not isolate quercetin's effect.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Exercise: Performance, Recovery and Muscle. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The combination reduced reported pain and loss of jumping performance; race times did not improve.
  • The recorded outcome domains were Exercise performance or recovery; Symptoms and quality of life.
  • The result applies to the tested exposure: Mango-leaf extract 140 mg plus quercetin 140 mg before exercise, with three further doses 8 hours apart; 24-hour dosing around a damaging exercise bout.

What this study can and cannot tell us

  • Multi-ingredient acute intervention. Sex-specific biomarker findings and recovery endpoints do not isolate quercetin's effect.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: accessible full text and indexed metadata. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology