Tier 1 — highest

Impact of quercetin on systemic levels of inflammation: a meta-analysis of randomised controlled human trials

Qiaowen Ou, Zhifen Zheng, Yongyi Zhao, Weiqun Lin
International journal of food sciences and nutrition 2020 71(2):152-163

Bibliography

PubMed
PMID 31213101
DOI
10.1080/09637486.2019.1627515
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignMeta-analysis of randomized controlled human trials
ModelHuman evidence synthesis
SampleOutcome-specific sets: 6 CRP, 5 IL-6, and 4 TNF-alpha studies
InterventionQuercetin supplementation across trial-specific regimens
DurationPublished studies to the review search cutoff
EndpointsInflammatory measures

What the study showed, in plain terms

Published in 2020, this source examined immunity and respiratory health. Its evidence base was Outcome-specific sets: 6 CRP, 5 IL-6, and 4 TNF-alpha studies. It evaluated Quercetin supplementation across trial-specific regimens across Published studies to the review search cutoff.

Overall CRP, IL-6, and TNF-alpha did not improve; selected subgroups showed reductions.

Subgroup findings should not override null overall results. Heterogeneity and overlapping underlying trials help explain differences from other inflammation reviews.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Immune Health, Colds and COVID-19. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Overall CRP, IL-6, and TNF-alpha did not improve; selected subgroups showed reductions.
  • The recorded outcome domains were Inflammatory measures.
  • This synthesis reuses the included study populations; it is not an additional randomized participant cohort.

What this study can and cannot tell us

  • Subgroup findings should not override null overall results. Heterogeneity and overlapping underlying trials help explain differences from other inflammation reviews.
  • Pooled estimates depend on the included trials and may share participants with companion publications or other reviews. A statistically significant surrogate outcome does not establish disease prevention.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 1
Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials
M Mohammadi-Sartang et al. · European journal of clinical nutrition · 2017

Citation network

Articles citing this research paper

2 articles

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology