Tier 2 — strong

Intestinal phase-II metabolism of quercetin in HT29 cells, 3D human intestinal tissues and in healthy volunteers: a qualitative comparison using LC-IMS-MS and LC-HRMS

Clément Chalet, Boudewijn Hollebrands, Guus S Duchateau, Patrick Augustijns
Xenobiotica; the fate of foreign compounds in biological systems 2019 49(8):945-952

Bibliography

PubMed
PMID 30085847
DOI
10.1080/00498254.2018.1509246
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignHuman intestinal sampling and comparative laboratory metabolism study
ModelHuman intervention research
SampleHealthy volunteers with intestinal-fluid sampling plus HT29 and 3D tissue models
InterventionQuercetin exposure across human and laboratory systems
DurationSampling schedules varied by model
EndpointsExposure and pharmacokinetics

What the study showed, in plain terms

Published in 2019, this source examined forms, absorption and food sources. Design: Human intestinal sampling and comparative laboratory metabolism study. Sample/model: Healthy volunteers with intestinal-fluid sampling plus HT29 and 3D tissue models. The exposure or intervention was Quercetin exposure across human and laboratory systems. Follow-up or treatment period: Sampling schedules varied by model.

Human intestinal metabolite profiles differed from HT29 cell profiles; 3D tissues reproduced more of the human pattern.

Qualitative metabolism study. Cell-model differences caution against translating laboratory exposure results directly into human outcomes.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin Forms: Dihydrate, Phytosome, Liposomal and Glycosides. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Human intestinal metabolite profiles differed from HT29 cell profiles; 3D tissues reproduced more of the human pattern.
  • The recorded outcome domains were Exposure and pharmacokinetics.
  • The result applies to the tested exposure: Quercetin exposure across human and laboratory systems; Sampling schedules varied by model.

What this study can and cannot tell us

  • Qualitative metabolism study. Cell-model differences caution against translating laboratory exposure results directly into human outcomes.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology