Tier 4 — mechanistic

Quercetin and iron metabolism: What we know and what we need to know

Lin Xiao, Gang Luo, Yuhan Tang, Ping Yao
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 114:190

Bibliography

PubMed
PMID 29432835
DOI
10.1016/j.fct.2018.02.022
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignNarrative mechanistic review of iron metabolism
ModelNarrative or mixed evidence review
SampleLaboratory, animal, and human-relevant evidence; no new trial cohort
InterventionQuercetin and iron-related pathways
DurationLiterature available at publication
EndpointsOxidative-stress measures; Protein activity, binding or signaling

What the study showed, in plain terms

Published in 2018, this source examined safety, interactions and special populations. Its evidence base was Laboratory, animal, and human-relevant evidence; no new trial cohort. It evaluated Quercetin and iron-related pathways across Literature available at publication.

The review discusses iron binding, redox effects, and regulation of iron handling beyond simple chelation.

Mechanistic interactions do not establish a clinical treatment for iron overload or quantify the effect of usual supplements on human iron status.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin Side Effects and Safety: A Practical Guide. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The review discusses iron binding, redox effects, and regulation of iron handling beyond simple chelation.
  • The recorded outcome domains were Oxidative-stress measures; Protein activity, binding or signaling.

What this study can and cannot tell us

  • Mechanistic interactions do not establish a clinical treatment for iron overload or quantify the effect of usual supplements on human iron status.
  • The conclusions inherit the limitations of the underlying studies. A narrative interpretation or guideline recommendation is not a new randomized treatment comparison.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 2
Safety Aspects of the Use of Quercetin as a Dietary Supplement
Susanne Andres et al. · Molecular nutrition & food research · 2018
Tier 2
A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
M Harwood et al. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2007

Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology