Tier 2 — strong

A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties

M Harwood, B Danielewska-Nikiel, J F Borzelleca, G W Flamm, G M Williams, T C Lines
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007 45(11):2179

Bibliography

PubMed
PMID 17698276
DOI
10.1016/j.fct.2007.05.015
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignCritical narrative toxicology and safety review
ModelNarrative or mixed evidence review
SampleGenotoxicity, animal, and human evidence; no new participant cohort
InterventionQuercetin exposures relevant to food addition
DurationPublished evidence to the 2007 review
EndpointsSource-specific outcomes described in the key findings

What the study showed, in plain terms

Published in 2007, this source examined safety, interactions and special populations. Its evidence base was Genotoxicity, animal, and human evidence; no new participant cohort. It evaluated Quercetin exposures relevant to food addition across Published evidence to the 2007 review.

The authors interpreted available in vivo evidence as supporting food-use safety despite some positive in vitro mutagenicity findings.

An older food-safety assessment is not proof of indefinite high-dose supplement safety, safety in every risk group, or absence of drug interactions.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin Side Effects and Safety: A Practical Guide. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The authors interpreted available in vivo evidence as supporting food-use safety despite some positive in vitro mutagenicity findings.
  • The recorded outcome domains were Source-specific outcomes described in the key findings.

What this study can and cannot tell us

  • An older food-safety assessment is not proof of indefinite high-dose supplement safety, safety in every risk group, or absence of drug interactions.
  • The conclusions inherit the limitations of the underlying studies. A narrative interpretation or guideline recommendation is not a new randomized treatment comparison.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 2
Safety Aspects of the Use of Quercetin as a Dietary Supplement
Susanne Andres et al. · Molecular nutrition & food research · 2018
Tier 4
Quercetin and iron metabolism: What we know and what we need to know
Lin Xiao et al. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology