Tier 2 — strong

Acute intake of quercetin from onion skin extract does not influence postprandial blood pressure and endothelial function in overweight-to-obese adults with hypertension: a randomized, double-blind, placebo-controlled, crossover trial

Verena Brüll, Constanze Burak, Birgit Stoffel-Wagner, Siegfried Wolffram, Georg Nickenig, Cornelius Müller, Peter Langguth, Birgit Alteheld, Rolf Fimmers, Peter Stehle, Sarah Egert
European journal of nutrition 2017 56(3):1347

Bibliography

PubMed
PMID 26924303
DOI
10.1007/s00394-016-1185-1
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized double-blind placebo-controlled crossover meal study
ModelHuman intervention research
Sample22 overweight-to-obese adults with hypertension
InterventionOnion-skin extract providing quercetin 54 mg with a high-energy meal
DurationAcute assessment through 4 hours
EndpointsBlood pressure

What the study showed, in plain terms

Published in 2017, this source examined cardiovascular and metabolic health. Design: Randomized double-blind placebo-controlled crossover meal study. Sample/model: 22 overweight-to-obese adults with hypertension. The exposure or intervention was Onion-skin extract providing quercetin 54 mg with a high-energy meal. Follow-up or treatment period: Acute assessment through 4 hours.

Quercetin did not attenuate post-meal blood pressure, vascular or metabolic responses.

Single-meal study of a specific extract. Findings concern acute responses, not long-term treatment.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin and Blood Pressure: How Large Is the Effect?. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Quercetin did not attenuate post-meal blood pressure, vascular or metabolic responses.
  • The recorded outcome domains were Blood pressure.
  • The result applies to the tested exposure: Onion-skin extract providing quercetin 54 mg with a high-energy meal; Acute assessment through 4 hours.

What this study can and cannot tell us

  • Single-meal study of a specific extract. Findings concern acute responses, not long-term treatment.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology