Tier 2 — strong

Quercetin Reduces Vascular Senescence and Inflammation in Symptomatic Male but Not Female Coronary Artery Disease Patients

Pauline Mury, Olina Dagher, Annik Fortier, Ariel Diaz, Yoan Lamarche, Pierre-Emmanuel Noly, Marina Ibrahim, Pierre Pagé, Philippe Demers, Denis Bouchard, Pierre-Luc Bernier, Nancy Poirier, Emmanuel Moss, Nicolas Durrleman, Hughes Jeanmart, Michel Pellerin, Guillaume Lettre, Nathalie Thorin-Trescases, Michel Carrier, Eric Thorin
Aging cell 2025 24(8):e70108

Bibliography

PubMed
PMID 40375481
PubMed Central
PMC12341813
DOI
10.1111/acel.70108
Funding
Reported funding/support: Canadian Institutes of Health Research10.13039/501100000024 PJT‐162446PJT‐166110
Competing interests
Reported disclosure: The authors declare no conflicts of interest.

Study snapshot

DesignRandomized double-blind placebo-controlled surgical trial
ModelHuman intervention research
Sample97 coronary-bypass patients; 78 men
InterventionQuercetin 500 mg twice daily or placebo
Duration2 days before surgery through hospital discharge
EndpointsInflammatory measures

What the study showed, in plain terms

Published in 2025, this source examined cardiovascular and metabolic health. Design: Randomized double-blind placebo-controlled surgical trial. Sample/model: 97 coronary-bypass patients; 78 men. The exposure or intervention was Quercetin 500 mg twice daily or placebo. Follow-up or treatment period: 2 days before surgery through hospital discharge.

Endothelial relaxation improved, primarily in men. The overall CRP difference was not significant, and female tissue analyses showed no comparable endothelial benefit.

Short surgical study with a small female subgroup and exploratory molecular analyses. It does not establish general anti-aging efficacy.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin and Blood Pressure: How Large Is the Effect?. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Endothelial relaxation improved, primarily in men.
  • The overall CRP difference was not significant, and female tissue analyses showed no comparable endothelial benefit.
  • The recorded outcome domains were Inflammatory measures.
  • The result applies to the tested exposure: Quercetin 500 mg twice daily or placebo; 2 days before surgery through hospital discharge.

What this study can and cannot tell us

  • Short surgical study with a small female subgroup and exploratory molecular analyses. It does not establish general anti-aging efficacy.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: accessible full text and indexed metadata. Missing method details, funding information or participant denominators are not inferred.

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Citation network

Articles citing this research paper

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Editorial review

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Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology