Tier 2 — strong

Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized, double-blind, placebo-controlled, crossover trial

James I Dower, Johanna M Geleijnse, Lieke Gijsbers, Peter L Zock, Daan Kromhout, Peter C H Hollman
The American journal of clinical nutrition 2015 101(5):914

Bibliography

PubMed
PMID 25934864
DOI
10.3945/ajcn.114.098590
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized double-blind placebo-controlled crossover trial
ModelHuman intervention research
Sample37 adults with elevated screening systolic pressure
InterventionQuercetin-3-glucoside 160 mg/day, epicatechin 100 mg/day or placebo
Duration4-week treatment periods
EndpointsGlucose and insulin measures

What the study showed, in plain terms

Published in 2015, this source examined cardiovascular and metabolic health. Design: Randomized double-blind placebo-controlled crossover trial. Sample/model: 37 adults with elevated screening systolic pressure. The exposure or intervention was Quercetin-3-glucoside 160 mg/day, epicatechin 100 mg/day or placebo. Follow-up or treatment period: 4-week treatment periods.

Quercetin did not improve the primary flow-mediated dilation endpoint, insulin resistance or other measured cardiovascular risk factors.

A related glycoside and surrogate outcomes. Other papers from this registered cohort are companion analyses.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin and Blood Pressure: How Large Is the Effect?. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Quercetin did not improve the primary flow-mediated dilation endpoint, insulin resistance or other measured cardiovascular risk factors.
  • The recorded outcome domains were Glucose and insulin measures.
  • The result applies to the tested exposure: Quercetin-3-glucoside 160 mg/day, epicatechin 100 mg/day or placebo; 4-week treatment periods.

What this study can and cannot tell us

  • A related glycoside and surrogate outcomes. Other papers from this registered cohort are companion analyses.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Companion or correction records are linked below. They should not be counted automatically as independent replications; see the individual source notes for the relationship.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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James I Dower et al. · The Journal of nutrition · 2015
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Quercetin, but Not Epicatechin, Decreases Plasma Concentrations of Methylglyoxal in Adults in a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial with Pure Flavonoids
Mathias D G Van den Eynde et al. · The Journal of nutrition · 2018
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Citation network

Articles citing this research paper

1 article

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology