Tier 2 — strong

Simultaneous ingestion of high-methoxy pectin from apple can enhance absorption of quercetin in human subjects

Tomohiko Nishijima, Yoshiki Takida, Yasuo Saito, Takayuki Ikeda, Kunihisa Iwai
The British journal of nutrition 2015 113(10):1531

Bibliography

PubMed
PMID 25865751
DOI
10.1017/S0007114515000537
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized crossover food-matrix absorption study
ModelHuman intervention research
Sample19 healthy volunteers; a 6-person dose-response subgroup
InterventionQuercetin drink containing 100 mg quercetin with or without apple pectin
DurationSingle-dose comparisons; urine collected for 24 hours
EndpointsExposure and pharmacokinetics

What the study showed, in plain terms

Published in 2015, this source examined forms, absorption and food sources. Design: Randomized crossover food-matrix absorption study. Sample/model: 19 healthy volunteers; a 6-person dose-response subgroup. The exposure or intervention was Quercetin drink containing 100 mg quercetin with or without apple pectin. Follow-up or treatment period: Single-dose comparisons; urine collected for 24 hours.

Pectin increased urinary recovery of quercetin metabolites, with effects varying by amount and methylation level.

Short pharmacokinetic study. Urinary recovery does not establish improved clinical outcomes or a general supplement regimen.

Continue with Quercetin Data Center

For topic-level interpretation, read Best Time to Take Quercetin: Meals, Morning or Night?. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Pectin increased urinary recovery of quercetin metabolites, with effects varying by amount and methylation level.
  • The recorded outcome domains were Exposure and pharmacokinetics.
  • The result applies to the tested exposure: Quercetin drink containing 100 mg quercetin with or without apple pectin; Single-dose comparisons; urine collected for 24 hours.

What this study can and cannot tell us

  • Short pharmacokinetic study. Urinary recovery does not establish improved clinical outcomes or a general supplement regimen.
  • A change in blood exposure or a metabolic marker is not a demonstrated improvement in symptoms, disease events or lifespan. The tested formulation and co-administered medicines matter.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology