Tier 2 — strong

Dietary fat increases quercetin bioavailability in overweight adults

Yi Guo, Eunice Mah, Catherine G Davis, Thunder Jalili, Mario G Ferruzzi, Ock K Chun, Richard S Bruno
Molecular nutrition & food research 2013 57(5):896

Bibliography

PubMed
PMID 23319447
DOI
10.1002/mnfr.201200619
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized crossover absorption study
ModelHuman intervention research
Sample9 adults with overweight or obesity
InterventionQuercetin aglycone 1,095 mg with breakfasts containing less than 0.5 g, 4 g, or 15.4 g fat
DurationSingle-dose comparisons with 24-hour sampling
EndpointsExposure and pharmacokinetics

What the study showed, in plain terms

Published in 2013, this source examined forms, absorption and food sources. Design: Randomized crossover absorption study. Sample/model: 9 adults with overweight or obesity. The exposure or intervention was Quercetin aglycone 1,095 mg with breakfasts containing less than 0.5 g, 4 g, or 15.4 g fat. Follow-up or treatment period: Single-dose comparisons with 24-hour sampling.

The highest-fat breakfast increased peak quercetin concentration by about 45% and exposure by about 32% relative to the fat-free meal.

Small acute pharmacokinetic experiment. Increased exposure does not establish better health outcomes or justify a high-fat diet.

Continue with Quercetin Data Center

For topic-level interpretation, read Best Time to Take Quercetin: Meals, Morning or Night?. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The highest-fat breakfast increased peak quercetin concentration by about 45% and exposure by about 32% relative to the fat-free meal.
  • The recorded outcome domains were Exposure and pharmacokinetics.
  • The result applies to the tested exposure: Quercetin aglycone 1,095 mg with breakfasts containing less than 0.5 g, 4 g, or 15.4 g fat; Single-dose comparisons with 24-hour sampling.

What this study can and cannot tell us

  • Small acute pharmacokinetic experiment. Increased exposure does not establish better health outcomes or justify a high-fat diet.
  • A change in blood exposure or a metabolic marker is not a demonstrated improvement in symptoms, disease events or lifespan. The tested formulation and co-administered medicines matter.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology