Tier 2 — strong

Enriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules

Sarah Egert, Siegfried Wolffram, Beate Schulze, Peter Langguth, Eva Maria Hubbermann, Karin Schwarz, Berit Adolphi, Anja Bosy-Westphal, Gerald Rimbach, Manfred James Müller
The British journal of nutrition 2012 107(4):539

Bibliography

PubMed
PMID 21774840
DOI
10.1017/S0007114511003242
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized single-blind diet-controlled crossover absorption study
ModelHuman intervention research
Sample6 healthy young women
InterventionApproximately 130 mg quercetin equivalents in enriched cereal bars or powder-filled capsules
DurationSingle-dose periods with 24-hour sampling
EndpointsExposure and pharmacokinetics

What the study showed, in plain terms

Published in 2012, this source examined forms, absorption and food sources. Design: Randomized single-blind diet-controlled crossover absorption study. Sample/model: 6 healthy young women. The exposure or intervention was Approximately 130 mg quercetin equivalents in enriched cereal bars or powder-filled capsules. Follow-up or treatment period: Single-dose periods with 24-hour sampling.

The tested bar produced substantially higher plasma exposure than the tested capsule.

Very small formulation-specific experiment; the bar also contained a minor glucoside fraction. It does not establish superiority of all bars over all capsules or better health outcomes.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin Forms: Dihydrate, Phytosome, Liposomal and Glycosides. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The tested bar produced substantially higher plasma exposure than the tested capsule.
  • The recorded outcome domains were Exposure and pharmacokinetics.
  • The result applies to the tested exposure: Approximately 130 mg quercetin equivalents in enriched cereal bars or powder-filled capsules; Single-dose periods with 24-hour sampling.

What this study can and cannot tell us

  • Very small formulation-specific experiment; the bar also contained a minor glucoside fraction. It does not establish superiority of all bars over all capsules or better health outcomes.
  • A change in blood exposure or a metabolic marker is not a demonstrated improvement in symptoms, disease events or lifespan. The tested formulation and co-administered medicines matter.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology