Tier 2 — strong

No evidence for a thermic effect of the dietary flavonol quercetin: a pilot study in healthy normal-weight women

Sarah Egert, Gerald Rimbach, Manfred James Müller
European journal of applied physiology 2011 111(5):869

Bibliography

PubMed
PMID 20924595
DOI
10.1007/s00421-010-1674-5
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized double-blind placebo-controlled crossover calorimetry pilot
ModelHuman intervention research
Sample6 healthy normal-weight women
InterventionQuercetin aglycone 150 mg or placebo
Duration3-hour acute measurement and 24-hour follow-up
EndpointsSource-specific outcomes described in the key findings

What the study showed, in plain terms

Published in 2011, this source examined liver and metabolic health. Design: Randomized double-blind placebo-controlled crossover calorimetry pilot. Sample/model: 6 healthy normal-weight women. The exposure or intervention was Quercetin aglycone 150 mg or placebo. Follow-up or treatment period: 3-hour acute measurement and 24-hour follow-up.

Resting energy expenditure and respiratory quotient were not improved relative to placebo.

Very small acute trial; it provides no support for a thermogenic or weight-loss effect under the tested conditions.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Weight Loss, Blood Sugar and Fatty Liver: Human Evidence. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Resting energy expenditure and respiratory quotient were not improved relative to placebo.
  • The recorded outcome domains were Source-specific outcomes described in the key findings.
  • The result applies to the tested exposure: Quercetin aglycone 150 mg or placebo; 3-hour acute measurement and 24-hour follow-up.

What this study can and cannot tell us

  • Very small acute trial; it provides no support for a thermogenic or weight-loss effect under the tested conditions.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 2
Quercetin with vitamin C and niacin does not affect body mass or composition
Amy M Knab et al. · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2011

Citation network

Articles citing this research paper

1 article

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology