Tier 2 — strong

A Pilot Trial of Nicotinamide Riboside and Coenzyme Q10 on Inflammation and Oxidative Stress in CKD

Ahmadi A, Valencia AP, Begue G, Norman JE, Fan S, Durbin-Johnson BP, Jenner BN, Campbell MD, Reyes G, Kapahi P, Himmelfarb J, de Boer IH, Marcinek DJ, Kestenbaum BR, Gamboa JL, Roshanravan B
Clinical journal of the American Society of Nephrology : CJASN 2025 20; 3; 346-357

Bibliography

PubMed
PMID 39847432
PubMed Central
PMC11905997
DOI
10.2215/cjn.0000000624
Funding
Indexed grant support includes NIDDK NIH HHS, Dialysis Clinics. The complete funding declaration is not specified in the accessible abstract.
Competing interests
The publication provides individual declarations of financial or nonfinancial interests; consult the source for the complete disclosures.

Study snapshot

DesignSecondary or companion analysis of an existing human intervention
ModelHuman participants
Sample25 CKD participants; cellular bioenergetics subset of 14
InterventionNR 1000 mg/day, CoQ10 1200 mg/day or placebo in separate periods
Duration6 weeks per treatment period
EndpointsInflammatory biomarkers; isoprostanes; immune-cell bioenergetics

What the study showed, in plain terms

This companion report found selected oxidative-stress and immune-cell bioenergetic changes after NR. Inflammatory effects were mixed rather than uniformly anti-inflammatory.

Key findings

NR increased IL-2; selected five-series isoprostanes decreased after adjustment.

What this study can and cannot tell us

Same trial cohort as PMID 37159264. Numerous exploratory comparisons; several nominal findings did not survive multiplicity adjustment.

Related papers in the corpus

Tier 2
Randomized crossover clinical trial of coenzyme Q10 and nicotinamide riboside in chronic kidney disease
Armin Ahmadi et al. · JCI Insight · 2023

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology