Tier 4 — mechanistic

Nicotinamide Riboside Augments Human Macrophage Migration via SIRT3-Mediated Prostaglandin E2 Signaling

Wu J, Bley M, Steans RS, Meadows AM, Huffstutler RD, Tian R, Griffin JL, Sack MN

Cells 2024 13; 5; 455

Bibliography

PubMed: PMID 38474420
PubMed Central: PMC10931126
DOI: 10.3390/cells13050455
Funding: NHLBI intramural and UK MRC support. ChromaDex provided NR and placebo through research agreements.
Competing interests: The relevant laboratory reported receiving study materials from ChromaDex without direct financial support or compensation.

Design	Human clinical and laboratory mechanistic study
Model	Human participants, primary monocytes and cultured macrophages
Sample	35 healthy participants in the cited clinical cohort; separate cell experiments
Intervention	Oral NR in a clinical component and direct exposure of cultured macrophages
Duration	Short-term clinical supplementation with separate laboratory time courses
Endpoints	Macrophage migration; PGE2; SIRT3 signaling

The study linked NR, SIRT3 and prostaglandin E2 signaling to macrophage migration using human samples and cell experiments.

The study linked NR, SIRT3 and prostaglandin E2 signaling to macrophage migration using human samples and cell experiments.

Mechanistic endpoints and a small clinical component do not establish wound-healing efficacy in patients.

Editorial review

Last verified 22 October 2026