Tier 2 — strong

Effect of the Mediterranean diet supplemented with nicotinamide riboside and pterostilbene and/or coconut oil on anthropometric variables in amyotrophic lateral sclerosis. A pilot study

Carrera-Juliá S, Estrela JM, Zacarés M, Navarro MÁ, Vega-Bello MJ, de la Rubia Ortí JE, Moreno ML, Drehmer E
Frontiers in nutrition 2023 10; 1232184

Bibliography

PubMed
PMID 37810917
PubMed Central
PMC10556480
DOI
10.3389/fnut.2023.1232184
Funding
Funding details are not specified in the accessible publication information.
Competing interests
The publication provides individual declarations of financial or nonfinancial interests; consult the source for the complete disclosures.

Study snapshot

DesignRandomized controlled study of a multi-ingredient or combined intervention
ModelHuman participants
Sample40 people with ALS in four groups
InterventionNR 15 mg/kg/day plus pterostilbene 2.5 mg/kg/day, with diet and/or coconut oil cointerventions
Duration4 months
EndpointsAnthropometry; muscle and fat measures

What the study showed, in plain terms

The pilot reported changes in muscle and fat measures under several nutritional interventions.

Key findings

The pilot reported changes in muscle and fat measures under several nutritional interventions.

What this study can and cannot tell us

Diet and multiple active supplements complicate attribution; anthropometric changes do not establish slower ALS progression or longer survival.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology