Tier 3 — preclinical

Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm

Marinescu AG, Chen J, Holmes HE, Guarente L, Mendes O, Morris M, Dellinger RW
International journal of toxicology 2020 39; 4; 307-320

Bibliography

PubMed
PMID 32715855
DOI
10.1177/1091581820927406
Funding
Funding details are not specified in the accessible publication information.
Competing interests
A complete competing-interest declaration is not specified in the accessible publication information.

Study snapshot

DesignPreclinical animal study with supporting assays as applicable
ModelRats
SampleSprague-Dawley rat cohorts
InterventionSynthetic NR-E at 300, 500 or 1200 mg/kg/day
Duration90 days with a 28-day recovery arm
EndpointsModel-specific physiological outcomes; Biochemical or functional measures reported in the study

What the study showed, in plain terms

The rat study reported no treatment-related mortality and sex-specific NOAELs, with lower weight gain affecting the male high-dose assessment.

Key findings

Reported NOAELs were 500 mg/kg/day for males and 1200 mg/kg/day for females.

What this study can and cannot tell us

Formulation-specific animal toxicology does not establish long-term human safety. Consult the published corrigendum alongside the original report.

Related papers in the corpus

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Corrigendum to "Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm"
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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology