Tier 4 — mechanistic

Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC

Turck D, Castenmiller J, de Henauw S, Hirsch-Ernst KI, Kearney J, Maciuk A, Mangelsdorf I, McArdle HJ, Naska A, Pelaez C, Pentieva K, Siani A, Thies F, Tsabouri S, Vinceti M, Cubadda F, Engel KH, Frenzel T, Heinonen M, Marchelli R, Neuhäuser-Berthold M, Pöting A, Poulsen M, Sanz Y, Schlatter JR, van Loveren Agnès de Sesmaisons-Lecarré H, Germini A, Knutsen HK
EFSA journal. European Food Safety Authority 2019 17; 8; e05775

Bibliography

PubMed
PMID 32626405
PubMed Central
PMC7009190
Funding
Funding details are not specified in the accessible publication information.
Competing interests
A complete competing-interest declaration is not specified in the accessible publication information.

Study snapshot

DesignPublished expert scientific risk assessment
ModelPublished scientific risk assessment
SampleRegulatory assessment of manufacturing, animal and human data
InterventionSpecified NR chloride novel-food ingredient and proposed uses
DurationPublished 2019 assessment; studies had varying durations
EndpointsIngredient composition, bioavailability and safety assessment

What the study showed, in plain terms

The EFSA opinion evaluated the ingredient’s composition, bioavailability and safety under specified proposed conditions of use.

Key findings

The EFSA opinion evaluated the ingredient’s composition, bioavailability and safety under specified proposed conditions of use.

What this study can and cannot tell us

A historical ingredient assessment is not an efficacy trial, a current legal-status summary or an unrestricted dosing recommendation for every population.

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