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The effects of whey, pea, and collagen protein supplementation beyond the recommended dietary allowance on integrated myofibrillar protein synthetic rates in older males: a randomized controlled trial
The American Journal of Clinical Nutrition
2024
120(1):34–46
Bibliography
- PubMed
- PMID 38762187
- PubMed Central
- PMC11291473
- Funding
- The study included a research contract from Roquette Frères; trainee support also included Canadian Institutes of Health Research and Natural Sciences and Engineering Research Council awards. The paper states funders had no role in study design, data collection/analysis, manuscript preparation, or publication decision.
- Competing interests
- Stuart M. Phillips reported research funding, honoraria/advisory relationships and patents outside the submitted work; other disclosures are detailed in the paper. These relationships should be considered when interpreting the study.
Study snapshot
| Design | Double-blind randomized controlled feeding trial with deuterated water and muscle biopsies |
|---|---|
| Model | Men aged 72 ± 4 years consuming controlled protein at the RDA before supplementation |
| Sample | 31 healthy older men; whey n=10, pea n=11, collagen n=10 |
| Intervention | Additional 50 g/day whey, pea or collagen (25 g twice daily) above the RDA |
| Duration | 8-day supplementation following 7-day control |
| Endpoints | Integrated myofibrillar muscle protein synthesis; Postprandial amino acids; Anabolic signaling |
What the study showed, in plain terms
Key findings
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Biohack Blueprint analyses that reference this study in their evidence base.
- Collagen Peptides for Muscle Growth & Recovery: The EvidenceCollagen is less effective than complete proteins for direct muscle protein synthesis, while some training studies report connective-tissue or body-composition effects with...Read analysis
- Collagen vs Whey Protein: Muscle Growth & RecoveryWhey has stronger direct evidence for muscle protein synthesis; collagen has a separate, formulation-specific literature on connective tissue, joints, bone and skin....Read analysis
- Collagen Daily Dose: Hydrolysed Collagen Dosage GuideHuman studies use different collagen doses for different outcomes, with no universally established daily dose. Here are the studied ranges for skin,...Read analysis
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