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Modulating stress and sleep through a multi-compound dietary supplement: a randomized, double-blind, placebo-controlled trial
Journal of the International Society of Sports Nutrition
2026
23(1):2740227
Bibliography
- PubMed
- PMID 42829807
- PubMed Central
- PMC13644447
- Funding
- Supported by Momentous LLC under Grant 10014583. Gianna F. Mastrofini was also supported in part by NIH-NIGMS Grant T32-GM081740.
- Competing interests
- The authors reported no potential conflict of interest. Finished study products were produced by Momentous LLC, which funded the study.
Study snapshot
| Design | Randomized, double-blind, placebo-controlled four-group human trial |
|---|---|
| Model | Healthy physically active adults |
| Sample | 103 participants completed the study: AMPM n=25, AM n=26, PM n=25, placebo n=27 |
| Intervention | Evening active formula: 2 g magnesium L-threonate delivering 145 mg magnesium, 200 mg L-theanine and 50 mg apigenin from grapefruit; morning active formula: 600 mg ashwagandha plus 300 mg Rhodiola rosea. Four groups received combinations of active or placebo AM/PM products. |
| Duration | 4 weeks total: 1 baseline week, 2 supplementation weeks and 1 washout week |
| Endpoints | PROMIS subjective sleep measures; Pittsburgh Sleep Quality Index; Wearable-derived objective sleep; Perceived stress; Positive affect; Wake after sleep onset |
What the study showed, in plain terms
Key findings
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