Tier 1 — highest

Monthly high-dose vitamin D supplementation does not increase kidney stone risk or serum calcium: results from a randomized controlled trial

Zarintaj Malihi, Carlene M M Lawes, Zhenqiang Wu, Ying Huang, Debbie Waayer, Les Toop, Kay-Tee Khaw, Carlos A Camargo, Robert Scragg
The American journal of clinical nutrition 2019 109(6):1578-1587

Bibliography

PubMed
PMID 31005969
DOI
10.1093/ajcn/nqy378
Funding
Support is recorded from Cancer Research UK, Medical Research Council. See the original publication for grant and material-support details.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignSafety analysis of the randomized ViDA trial
ModelHuman participants
Sample5,110 adults; serum calcium assessed in an approximately 8% subsample
InterventionVitamin D3 100,000 IU monthly or placebo
DurationMedian 3.3 years
EndpointsReported kidney stones; Stone-related hospitalization; Hypercalcemia

What the study showed, in plain terms

This publication examines reported kidney stones, stone-related hospitalization, hypercalcemia. Study population or evidence base: 5,110 adults; serum calcium assessed in an approximately 8% subsample. Intervention or exposure: Vitamin D3 100,000 IU monthly or placebo.

Key findings

The monthly regimen did not significantly increase kidney-stone events. The monitored subsample showed no excess hypercalcemia.

What this study can and cannot tell us

Serum calcium was measured in a subsample and stone events were relatively uncommon. A monthly bolus trial cannot establish universal safety of a different daily regimen.

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