Tier 4 — mechanistic

Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD+-CD38 Axis

Bing Si Li, Ri Zhe Zhu, Seok-Hee Lim, Jae Ho Seo, Byung-Min Choi
American Journal of Chinese Medicine 2021 49(5):1235-1250

Bibliography

PubMed
PMID 34049472
DOI
10.1142/S0192415X21500592

Study snapshot

DesignIn vitro cellular-senescence study
ModelWI-38 human embryonic lung fibroblasts under oxidative-stress-induced senescence
Sample
InterventionApigenin treatment in oxidative-stress and replicative-senescence cell models
Duration
EndpointsSenescence-associated β-galactosidase; SIRT1 activity; NAD+/NADH ratio; CD38 activity; Oxidative-stress markers

What the study showed, in plain terms

This cell study examined whether apigenin can reduce features of cellular senescence through the SIRT1-NAD+-CD38 axis.

Key findings

Apigenin reduced senescence-associated markers, increased the NAD+/NADH ratio and SIRT1 activity, and suppressed CD38 activity in the fibroblast models.

What this study can and cannot tell us

Human cells in a dish are not evidence of rejuvenation or anti-aging efficacy in people. Systemic exposure and clinically achievable concentrations are unresolved.

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Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology