Tier 3 — preclinical

Apigenin: a natural molecule at the intersection of sleep and aging

Daniel J. Kramer, Adiv A. Johnson
Frontiers in Nutrition 2024 11:1359176

Bibliography

PubMed
PMID 38476603
DOI
10.3389/fnut.2024.1359176

Study snapshot

DesignNarrative review
ModelMechanistic, animal and human apigenin/chamomile literature
Sample
Intervention
Duration
Endpoints

What the study showed, in plain terms

This review connects two major apigenin research themes: sleep biology and aging biology, including CD38 inhibition, NAD+ preservation and GABA-related sleep mechanisms.

Key findings

Animal studies suggest effects on sleep, cognition, inflammatory signaling and lifespan in model organisms. Human evidence is much thinner and often uses chamomile extract rather than isolated apigenin.

What this study can and cannot tell us

Clinical studies have not directly shown that isolated apigenin slows human aging, and chamomile effects cannot be attributed to apigenin alone.

Citation network

Articles citing this research paper

2 articles

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology