Tier 3 — preclinical

Hydroxyproline ingestion and urinary oxalate and glycolate excretion

John Knight, Jiang Jiang, Dean G Assimos, Ross P Holmes
Kidney International 2006 70(11):1929–1934

Bibliography

PubMed
PMID 17021603
PubMed Central
PMC2268952
Funding
The accessible PubMed/full-text metadata reviewed on 2026-09-23 did not expose a definitive funding statement for this 2006 study.
Competing interests
The accessible PubMed/full-text metadata reviewed on 2026-09-23 did not expose a definitive competing-interest statement for this 2006 study.

Study snapshot

DesignControlled-diet human feeding comparison of gelatin versus whey and gelatin dose challenges
ModelHealthy volunteers without known kidney stones
Sample10 participants in controlled gelatin/whey feeding comparison; additional dose-challenge experiments
Intervention30 g/day gelatin vs whey on controlled diet plus 5- and 10-g gelatin loads
DurationTwo 5-day controlled diet periods plus dose challenges
Endpoints24-hour urinary oxalate; Urinary glycolate; Plasma hydroxyproline

What the study showed, in plain terms

Controlled human feeding found that a high gelatin load increased urinary oxalate relative to whey, supporting a plausible hydroxyproline-to-oxalate pathway.

Key findings

30 g gelatin increased urinary oxalate 43% and glycolate 5.3-fold relative to whey; 5- and 10-g gelatin challenges changed excretion.

What this study can and cannot tell us

Gelatin rather than a defined modern hydrolysed-collagen brand; high 30-g comparison; only 10 participants; urinary surrogate, not prospective stone incidence. Do not infer 10 g collagen causes stones.

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