Tier 4 — mechanistic
Enhancement of pentobarbital-induced sleep by apigenin through chloride ion channel activation
Archives of Pharmacal Research
2012
35(2):367-373
Bibliography
- PubMed
- PMID 22370792
Study snapshot
| Design | In vivo mouse sleep study plus in vitro neuronal experiments |
|---|---|
| Model | Mice and primary cerebellar granule cells |
| Sample | |
| Intervention | Apigenin with pentobarbital and GABAergic/chloride-channel probes |
| Duration | |
| Endpoints | Sleep latency; Sleep duration; Chloride influx; GABAergic signaling |
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