Tier 2 — strong

Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active males with sleep complaints

Thomas C, Kingshott RN, Allott KM, Tang JCY, Dunn R, Fraser WD, Thorley J, Virgilio N, Prawitt J, Hogervorst E, Škarabot J, Clifford T
European journal of nutrition 2024 63(1):323-335

Bibliography

PubMed
PMID 37874350
PubMed Central
PMC10799148
DOI
10.1007/s00394-023-03267-w
Funding
Funding was not specified in the indexed abstract; the full funding disclosure has not been verified.
Competing interests
The accessible abstract does not establish the authors' competing interests; absence of a statement is not evidence of no conflicts.

Study snapshot

DesignRandomized controlled human intervention
ModelAdult humans
Sample13 physically active men with sleep complaints
InterventionCollagen peptides 15 g/day versus placebo, 1 hour before bed
Duration7 nights per crossover condition
EndpointsPolysomnographic awakenings; Subjective sleep measures; Cognition; Core temperature

What the study showed, in plain terms

A glycine-rich collagen preparation reduced awakenings in a small crossover trial. Most other sleep and physiological measures did not differ, and the study did not isolate glycine.

Key findings

  • PSG awakenings averaged 21.3 with collagen versus 29.3 with placebo.
  • Sleep quantity, latency and efficiency did not significantly differ.
  • Selected cognition results favored collagen; several other outcomes were null.

What this study can and cannot tell us

Collagen contains multiple amino acids and peptides; its effects cannot be assigned to glycine alone.

Small male-only trial with numerous measured outcomes and brief exposure.

Related papers in the corpus

Tier 2
Coingestion of Collagen With Whey Protein Prevents Postexercise Decline in Plasma Glycine Availability in Recreationally Active Men
Aussieker T et al. · International journal of sport nutrition and exercise metabolism · 2024
Tier 4
Control analysis of collagen synthesis by glycine, proline and lysine in bovine chondrocytes in vitro - Its relevance for medicine and nutrition
de Paz-Lugo P et al. · Bio Systems · 2023
Tier 4
mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β 1 -induced collagen biosynthesis
Selvarajah B et al. · Science signaling · 2019
Tier 4
A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis
Meléndez-Hevia E et al. · Journal of biosciences · 2009
Tier 3
Glycine induces MafG to regulate glutathione metabolism, inhibit chondrocyte ferroptosis, and upregulate plectin to improve osteoarthritis
Li Y et al. · Cellular signalling · 2026
Tier 2
The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review
Soh J et al. · GeroScience · 2024

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction