Tier 3 — preclinical
GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Old Mice Improves Brain Glutathione Deficiency, Oxidative Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation and Neurotrophic Factors to Reverse Age-Associated Cognitive Decline: Implications for Improving Brain Health in Aging
Antioxidants (Basel, Switzerland)
2023
12(5):1042
Bibliography
- PubMed
- PMID 37237908
- PubMed Central
- PMC10215265
- Funding
- Philanthropic support from the McNair Medical Institute at the Robert and Janice McNair Foundation.
- Competing interests
- No dedicated competing-interest declaration was identified in the retrieved full text; absence of a statement is not evidence of no conflicts.
Study snapshot
| Design | Controlled animal intervention with mechanistic experiments |
|---|---|
| Model | Young and old C57BL/6J mice |
| Sample | 24 male C57BL/6J mice: 8 young controls, 8 old controls and 8 old GlyNAC-treated mice; individual assays used subsamples |
| Intervention | Old mice received glycine 1.6 mg/g feed plus NAC 1.6 mg/g feed (0.16% each), pair-fed to old controls; young reference group |
| Duration | 8 weeks; old mice began at age 90 weeks and young controls were studied from 20 to 28 weeks |
| Endpoints | Maze performance; Brain glutathione; Mitochondrial and inflammatory measures |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
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