Tier 2 — strong

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial

Premranjan Kumar, Chun Liu, James Suliburk, Jean W Hsu, Raja Muthupillai, Farook Jahoor, Charles G Minard, George E Taffet, Rajagopal V Sekhar
J Gerontol A Biol Sci Med Sci 2023 78(1):75-89

Bibliography

PubMed
PMID 35975308
PubMed Central
PMC9879756
DOI
10.1093/gerona/glac135
Funding
Supported by NIH/National Institute on Aging grant R01AG041782 and a philanthropic research gift from the McNair Medical Institute at the Robert and Janice McNair Foundation; the publication states the funders had no role in trial conduct, analysis, interpretation or manuscript preparation.
Competing interests
None declared.

Study snapshot

DesignRandomized placebo-controlled clinical trial with young reference group
ModelHuman
Sample24 older adults randomized 12/12 plus 12 young adults
InterventionGlycine plus N-acetylcysteine versus alanine placebo
Duration16 weeks
EndpointsGlutathione; Oxidative stress; Mitochondrial function; Inflammation; Insulin resistance; Endothelial function; Strength; Cognition

What the study showed, in plain terms

Key randomized GlyNAC trial in older adults examining a broad panel of biological and functional outcomes.

Key findings

Multiple redox, metabolic and functional endpoints improved during GlyNAC compared with placebo in this small trial.

What this study can and cannot tell us

Small single-center pilot with many endpoints; GlyNAC findings cannot be attributed to NAC alone.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology