Tier 2 — strong

Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure

Díaz-Flores M, Cruz M, Duran-Reyes G, Munguia-Miranda C, Loza-Rodríguez H, Pulido-Casas E, Torres-Ramírez N, Gaja-Rodriguez O, Kumate J, Baiza-Gutman LA, Hernández-Saavedra D
Canadian journal of physiology and pharmacology 2013 91(10):855-860

Bibliography

PubMed
PMID 24144057
DOI
10.1139/cjpp-2012-0341
Funding
Funding was not specified in the indexed abstract; the full funding disclosure has not been verified.
Competing interests
The accessible abstract does not establish the authors' competing interests; absence of a statement is not evidence of no conflicts.

Study snapshot

DesignRandomized controlled human intervention
ModelAdult humans
Sample60 adults with metabolic syndrome; 30 glycine and 30 placebo
InterventionOral glycine 15 g/day versus placebo
Duration3 months
EndpointsLipid peroxidation; Antioxidant enzymes; Blood pressure

What the study showed, in plain terms

Glycine improved selected oxidative-stress markers in metabolic syndrome. The reported systolic-pressure benefit was seen in men, so the study should not be summarized as universal blood-pressure lowering.

Key findings

  • TBARS was approximately 25% lower with glycine than placebo.
  • Changes in enzyme activity and nitric-oxide-related measures varied by outcome and sex.
  • The systolic-pressure finding was a male subgroup result.

What this study can and cannot tell us

Small trial with multiple biomarker and subgroup comparisons.

The study does not establish prevention of cardiovascular events or a general antihypertensive effect.

Related papers in the corpus

Tier 2
The metabolic response to ingested glycine
Gannon MC et al. · The American journal of clinical nutrition · 2002
Tier 2
Effect of glycine on insulin secretion and action in healthy first-degree relatives of type 2 diabetes mellitus patients
González-Ortiz M et al. · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2001
Tier 2
Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes
Cruz M et al. · Journal of endocrinological investigation · 2008
Tier 4
Metabolic impact of dietary glycine supplementation in individuals with severe obesity
Tan HC et al. · Scientific reports · 2025
Tier 4
De Novo Glycine Synthesis Is Reduced in Adults With Morbid Obesity and Increases Following Bariatric Surgery
Tan HC et al. · Frontiers in endocrinology · 2022
Tier 4
Low serum glycine strengthens the association between branched-chain amino acids and impaired insulin sensitivity assessed before and after weight loss in a population with pre-diabetes: The PREVIEW_NZ cohort
Lim JJ et al. · Clinical nutrition (Edinburgh, Scotland) · 2024

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction