Tier 2 — strong

Effect of glycine on insulin secretion and action in healthy first-degree relatives of type 2 diabetes mellitus patients

González-Ortiz M, Medina-Santillán R, Martínez-Abundis E, von Drateln CR
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2001 33(6):358-360

Bibliography

PubMed
PMID 11456285
DOI
10.1055/s-2001-15421
Funding
Funding was not specified in the indexed abstract; the full funding disclosure has not been verified.
Competing interests
The accessible abstract does not establish the authors' competing interests; absence of a statement is not evidence of no conflicts.

Study snapshot

DesignRandomized controlled human intervention
ModelAdult humans
Sample12 healthy first-degree relatives of people with type 2 diabetes; 6 per arm
InterventionSingle oral glycine 5 g versus placebo before a clamp assessment
DurationAcute single-dose experiment
EndpointsEarly, late and total insulin secretion; Insulin action

What the study showed, in plain terms

Glycine increased insulin secretion in a small study of healthy adults with a family history of diabetes. Insulin action did not significantly improve, a distinction essential for interpreting the result.

Key findings

  • Early, late and total insulin responses favored glycine.
  • The study did not detect a change in insulin action.

What this study can and cannot tell us

Very small parallel trial with an acute physiological endpoint.

Greater secretion cannot be described as proven prevention or treatment of type 2 diabetes.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction