Tier 1 — highest

Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial

Heike A Bischoff-Ferrari, Bess Dawson-Hughes, E John Orav, Hannes B Staehelin, Otto W Meyer, Robert Theiler, Walter Dick, Walter C Willett, Andreas Egli
JAMA internal medicine 2016 176(2):175-83

Bibliography

PubMed
PMID 26747333
DOI
10.1001/jamainternmed.2015.7148
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample200 adults aged 70+ with a previous fall
InterventionMonthly D3 24,000 IU, 60,000 IU, or 24,000 IU plus calcifediol
Duration12 months
EndpointsLower-extremity function; Vitamin D status; Falls

What the study showed, in plain terms

This publication examines lower-extremity function, vitamin d status, falls. Study population or evidence base: 200 adults aged 70+ with a previous fall. Intervention or exposure: Monthly D3 24,000 IU, 60,000 IU, or 24,000 IU plus calcifediol.

Key findings

Higher-dose regimens raised vitamin D concentrations more but did not improve physical function and were associated with more falls than the lower-dose regimen.

What this study can and cannot tell us

Older adults with prior falls and intermittent treatment schedules. The calcifediol arm is not ordinary cholecalciferol, and there was no vitamin-D-free placebo.

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